Suppositories are the frequently used dosage forms prescribed rectally. However, suppositories have the limitation of prolonged action which may be attributed to the poor drug release properties of the suppository base. Surfactants can increase drug release to aid absorption by reducing interfacial tension between rectal fluids and the suppository base. The objective of this study was to examine the effect of different concentrations of sodium lauryl sulfate and tween 80 on the release of the drug paracetamol from palm kernel suppositories (HAMIN®). In this study, sodium lauryl sulfate (SLS) and tween 80 were used to examine their effect on drug release from paracetamol suppositories prepared using the HAMIN® base by the double casting method. The effect of SLS at concentrations of 0.25%, 0.5%, 0.75% and 1% w/w in suppositories was analyzed, the percentage increase in drug release was 26.6 respectively %, 28.9%, 37.4% and 84.6%. But at the same concentrations, Tween 80 showed a higher drug release rate than SLS, by 0.79, 8.9, 10, and 10 times, respectively. It can be concluded that although SLS increased drug release from the formulated suppositories, it was not as effective as Tween 80. Keywords: rectal route of administration, suppository, paracetamol, sodium lauryl sulfate, Tween 80, HAMIN® base. Introduction The oral route it is the most common route of drug administration in daily practice. However, in some circumstances the drugs may not be suitable for oral administration. Young children, the elderly, those suffering from nausea, vomiting and unconscious patients experience difficulty or are even unable to swallow medicines [1]. In these cases the rectal route becomes a good... middle of paper ......auryl sulfate (SLS) will be used at different concentrations in palm kernel-based paracetamol suppositories (HAMIN®) to examine its effect on the release of the drug and to determine the most favorable concentration of SLS on increasing the rate of absorption of paracetamol via the rectal route. Tween 80 is also known as polysorbate 80 or polyoxyethylene 20 Sorbitan mono-oleate. [13] It is an oleate ester of sorbitol and its anhydrides. It is an oily liquid, clear or slightly opalescent, yellow-brownish or colorless. Tween 80 is considered one of the most commonly used surfactants in the formulation of suppositories. [14] It is a non-ionic surfactant widely used in suppository formulation over the years, it was chosen to be compared with SLS on drug release rate at the same concentrations as such study has not previously reported with HAMIN® base.