Hypertrophic Cardiomyopathy: Effects on Young Athletes Alyssa Trimm 130568370 Wilfrid Laurier University Dr. Kalmar KP 122 Section AHypertrophic cardiomyopathy is a genetic disease of the heart, which makes the heart muscle thick and strong. The muscle often causes the cavity to decrease in size, forcing the heart to pump less blood. Hypertrophic cardiomyopathy is a leading cause of sudden death as prevention of blood flow causes cardiac arrest. More successful research into HCM is underway, including research into associated genetics and inheritance of genes. Unfortunately, this disorder affects many young athletes due to the increased stress of training on the heart. However, despite the use of new technologies such as electrocardiogram and transthoracic echocardiogram, strategies are limited, limiting new responses. This condition is said to begin in sacromeric proteins, as previous studies have called this disorder "sacromere disease." 6. The muscle around the left ventricle is so strong that it does not relax enough after contraction to regenerate blood in the heart 5. Hypertrophic cardiomyopathy has been discovered in about 50% of young individuals who die suddenly 5. A recent study noted genes associated with hypertrophic cardiomyopathy. Within 20 sacromere- and myofilament-related genes, 1400 mutations were detected in HCM 6. Mutations within the sacromere prevent normal shortening which causes the muscle to contract harder, reducing relaxation. However, not all mutated genes have been shown to cause hypertrophy. The MYH7 gene appears to be the most frequent as 25-35% of patients with mild or severe HCM had this gene present 6. Despite… half of the article… cardiomyopathy cohort. Hellenic J Cardiol. July-August 2013; 54(4):281-8.Dassen WRM, Kuipers H, Mihl C, et al. Cardiac remodeling: concentric versus eccentric hypertrophy in strength and endurance athletes. Neth Heart J. April 2008; 16(4):129-133.De Cecoo CN, Magri D, Piccirillo G, et al. Dispersion of myocardial repolarization and late gadolinium enhancement in patients with hypertrophic cardiomyopathy. Traffic log. Mar 2014Efthimiadis GK, Pagourelias ED, Pitsis A, et al. Surgical septal myectomy for hypertrophic cardiomyopathy in Greece: a first experience in a single center. Hellenic J Cardiol. Mar-Apr 2014;55(2):132-8.Rowland T. Sudden and unexpected death in young athletes: reconsidering "hypertrophic cardiomyopathy". PEDIATRICS, April 2009;123(4):1217-1222.Tang W, Yingchoncharoen T. Recent advances in hypertrophic cardiomyopathy. F1000First Representative Feb 2104;3;6;12.