Sepsis: Early Detection and Implementation of Sepsis Resuscitation PackageIntroductionSepsis is defined as the body's inflammatory response to an infection and can rapidly lead to the collapse of more organs and death. Early, targeted therapy using the sepsis resuscitation package introduced in the “Surviving Sepsis Campaign” is the treatment used worldwide to treat sepsis (Winterbottom 2012, pp 247). There are approximately one million cases of sepsis in the United States each year, and the number of deaths exceeds that of prostate cancer, breast cancer, and HIV/AIDS combined. Furthermore, more than a quarter of patients who develop sepsis will develop it in a medical-surgical unit, and severe sepsis is the most common cause of death among patients in non-coronary critical care units (Bernstein 2013, pp 24-25). of all nurses, not just critical care nurses, early signs and symptoms of sepsis and rapid implementation of the sepsis resuscitation package is critical to reducing the mortality rate of sepsis. Literature review “Early recognition and treatment of sepsis in the medical-surgical setting,” focuses on the role of the nurse in the ability to identify early signs of sepsis and quickly initiate the sepsis package. In the article “The critical role of nurses in identifying sepsis and implementing early goal-directed therapy,” we explain how interventions in the sepsis package reduced mortality from 37% to 30.8% in a study of two years conducted in 165 different healthcare facilities. sites. This article also details the clinical guidelines and timelines for implementing the sepsis bundle. The early stages of sepsis and clinical manifestations are discussed in the article "Helping Patients Survive Sepsis", with emphasis on the...... middle of the article ...... nurses are at the bedside of the bed 24 hours a day can have a dramatic impact on patient outcomes and reduce the overall mortality rate of sepsis using the evidence-based practices outlined in the Surviving Sepsis Campaign. Reference Page Bernstein, M., & Lynn, S. (2013). Helping patients survive sepsis. American Nurse Today, 8(1), 24-28. Retrieved from http://www.americannursetoday.com/article.Gobel, B., & Peterson, G.J. (2010). Sepsis and septic shock. Clinical Journal of Oncology Nursing, 14(6), 793-797. doi:10.1188/10.CJON.793-797.Tazbir, J. (2012). Early recognition and treatment of sepsis in the medical-surgical setting. MEDSURG Nursing, 21(4), 205-209.Winterbottom, F. (2012). Fundamental role of nurses in identifying sepsis and early implementation of goal-directed therapy. The Journal of Continuing Nursing Education, 43(6), 247-248. Doi:10:3928/00220124-20120523-33.