Prevalence of laboratory-confirmed influenza and outcomes by admission diagnosis in hospitalized adults and 4,915-27,174 deaths per year. The clinical presentation of influenza is widely variable in hospitalized adults. For example, a broad spectrum of illnesses was described during the 2009 H1N1 virus pandemic, ranging from mild upper respiratory tract infections and febrile influenza-like illnesses, to progressive pneumonia and gastrointestinal symptoms such as nausea and vomiting2. Variability in presentation may be attributed to factors such as age, underlying comorbid conditions, respiratory bacterial superinfections, and immune status. The most common symptoms observed in patients with laboratory-confirmed influenza include: cough, fever, sore throat, myalgias, and headache. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay The overlap of these influenza symptoms and other clinical features, including syndromes, with different respiratory pathogens and progressive diseases has been well documented. Indeed, with exacerbation of comorbidities, suspicion of influenza infection may be low and have a substantial impact on treatment, accuracy and timing of diagnoses by clinicians. Public health rationale: Much research has been conducted to describe the clinical symptoms of hospitalized patients with influenza infections. However, there is little work detailing the epidemiology of influenza presentation by admitting diagnosis, and the HAIVEN acute respiratory screening criteria provide a unique opportunity to do so. Understanding influenza in this way is important to increase awareness of the association between clinical diagnoses at presentation and their predictive value of influenza infections and associated outcomes. Additionally, increased awareness will aid infection prevention measures, testing and early detection of influenza and can help guide treatment models. Research question: What are the clinical diagnoses of influenza in hospitalized adult patients, and what is the difference in treatment patterns and outcomes? Primary objective(s): To determine the frequency of each diagnosis category and its proportion for influenza positivity and fever frequency by syndrome and age group. Determine the results of each diagnosis category. Data variables: all admission ICD codes within the first 24 hours of admission, all enrollment variables, all clinical test results, antiviral variables, and outcome variables. Methods and Analysis Plans: We will perform retrospective reviews on all HAIVEN enrollees over two seasons (2016-2018). Subjects will be classified into one of four categories defined as: Respiratory Infection Dx, Chronic High Risk Dx Exacerbation, Sepsis or Stroke Dx, Other Qualifying Symptoms (Appendix 1). These will be defined using the most relevant ICD codes within the first 24 hours of admission. The purpose of the fourth category is to include all enrolled subjects who have not received a diagnosis necessary for classification into one of the three categories. To determine the frequency of fever syndrome, it will not be included in the classification of subjects. A descriptive analysis will also be performed to determine the outcome of each diagnosis category and the delay between disease onset and hospitalization. Outcome will be defined as antiviral treatment, length of stay, admission to intensive care, length of stay on therapy.

Topic > Prevalence of laboratory-confirmed influenza and outcomes by admission diagnosis in hospitalized adults and 4,915-27,174 deaths per year. The clinical presentation of influenza is widely variable in hospitalized adults. For example, a broad spectrum of illnesses was described during the 2009 H1N1 virus pandemic, ranging from mild upper respiratory tract infections and febrile influenza-like illnesses, to progressive pneumonia and gastrointestinal symptoms such as nausea and vomiting2. Variability in presentation may be attributed to factors such as age, underlying comorbid conditions, respiratory bacterial superinfections, and immune status. The most common symptoms observed in patients with laboratory-confirmed influenza include: cough, fever, sore throat, myalgias, and headache. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay The overlap of these influenza symptoms and other clinical features, including syndromes, with different respiratory pathogens and progressive diseases has been well documented. Indeed, with exacerbation of comorbidities, suspicion of influenza infection may be low and have a substantial impact on treatment, accuracy and timing of diagnoses by clinicians. Public health rationale: Much research has been conducted to describe the clinical symptoms of hospitalized patients with influenza infections. However, there is little work detailing the epidemiology of influenza presentation by admitting diagnosis, and the HAIVEN acute respiratory screening criteria provide a unique opportunity to do so. Understanding influenza in this way is important to increase awareness of the association between clinical diagnoses at presentation and their predictive value of influenza infections and associated outcomes. Additionally, increased awareness will aid infection prevention measures, testing and early detection of influenza and can help guide treatment models. Research question: What are the clinical diagnoses of influenza in hospitalized adult patients, and what is the difference in treatment patterns and outcomes? Primary objective(s): To determine the frequency of each diagnosis category and its proportion for influenza positivity and fever frequency by syndrome and age group. Determine the results of each diagnosis category. Data variables: all admission ICD codes within the first 24 hours of admission, all enrollment variables, all clinical test results, antiviral variables, and outcome variables. Methods and Analysis Plans: We will perform retrospective reviews on all HAIVEN enrollees over two seasons (2016-2018). Subjects will be classified into one of four categories defined as: Respiratory Infection Dx, Chronic High Risk Dx Exacerbation, Sepsis or Stroke Dx, Other Qualifying Symptoms (Appendix 1). These will be defined using the most relevant ICD codes within the first 24 hours of admission. The purpose of the fourth category is to include all enrolled subjects who have not received a diagnosis necessary for classification into one of the three categories. To determine the frequency of fever syndrome, it will not be included in the classification of subjects. A descriptive analysis will also be performed to determine the outcome of each diagnosis category and the delay between disease onset and hospitalization. Outcome will be defined as antiviral treatment, length of stay, admission to intensive care, length of stay on therapy.