Dr. Samuel Alexander Kinnier Wilson was a British neurologist who first described a pathological change of the brain and liver in 1912. Wilson's work was based on several reports and studies from many studies including a German neurologist named Dr Carl Westphal in 1883, who called these changes “pseudosclerosis,” by a British neurologist named Sir William Gowers in 1888, who similarly identified the combination of neurological and liver disease (Rosencrantz and Schilsky, 2011, p. 246) and by Dr. Adolph Strümpell in 1898, who noticed cirrhosis liver problems. In 1948, a professor named John N. Cumings discovered the link to copper accumulation in both the liver and brain (News-Medical, 2014). Copper is an essential trace element critical to human health. It is needed for many different functions in the human body, including electron transport, the formation of the skin pigment melanin, maintenance of the myelin sheath covering nerves, aiding in the synthesis of phospholipids, and many other things (Subhranita, 2012 ). ). Copper is necessary for brain and liver function and is usually secreted in bile. However, sometimes copper is not excreted properly through the bile, and copper buildup can lead to some diseases, such as Wilson's disease, which is a genetic disorder that prevents the body from eliminating excess copper. This leads to a buildup of copper in the liver, which can eventually leak into the bloodstream, affecting the brain, eyes and other organs. This buildup can cause fatal damage to the affected organs. Wilson's disease is a rare genetic disorder, usually affecting around 1 in 40,000 people and having the same effect on both men and women. The design...... at the center of the article...... from https://www.genome.gov/27532725#al-3Bomford, A. (2007). Wilson's disease. Retrieved from http://www.britishlivertrust.org.uk/liver-information/liver-conditions/wilsons-disease/#Diagnosis Catana, A. M., & Medici, V. (2012). Liver transplant for Wilson's disease. World Journal of Hepatology, 4(1), 5-10. doi: 10.4254/wjh.v4.i1.5 Bowen, R. (2003, October 26). Liver histology: sinusoids. Retrieved from http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_sinusoids.htmlGilroy, R.K. (2013, October 1). Wilson's disease. Retrieved from http://emedicine.medscape.com/article/183456-overviewNetter, F.H. (2011). Surfaces and bed of the liver. In Atlas of Human Anatomy (5th ed., p. 277). Philadelphia, PA: Saunders/Elsevier. Stanislavsky, A., & Jones, J. (2014). Wilson's disease. Retrieved from http://radiopaedia.org/articles/wilson-disease-2