Technology has been the backbone of medicine since its inception, and its prevalence in medicine today is far-reaching and widespread. Through research and ingenuity, medical breakthroughs through technology can be attributed to many of the life-saving techniques used in medicine today. Likewise, technology can be attributed to much of healthcare spending, including the growing baby boomer population and their chronic conditions. Interestingly, telemedicine has boosted research over the past decade due to its promise to increase efficiency, quality of care and reduce costs. Despite this research, one of the most costly chronic diseases, cancer, is largely lacking in the literature regarding telemedicine. Additionally, policymakers have identified 30-day readmission rates as a way to measure health care quality, and payers have begun reducing payments for readmissions. A review of the literature regarding telemedicine and 30-day readmission rates will be explored, as well as a clinical trial design to study the effect of telemedicine on 30-day readmission rates in cancer patients. Problem Statement According to Mariotto, Yabroff, Shao, Feuer, and Brown (2011), cancer diagnosis and treatment is expected to cost the United States approximately $157.77 billion per year by 2020, and cancer prostate and breast will make up a significant portion of the costs. In general, cancer treatment involves numerous follow-up visits over five or more years, and the use of telemedicine with video conferencing is attractive because it has the “ability to create and maintain a therapeutic relationship and at the same time provide access and quality care”. to a patient in a remote geographical area... center of paper... Anglin, S. (2006). Success factors for telemedicine: a case study. International Journal of Medical Informatics, 75(10), 755-763. Prinz, L., Cramer, M., & Englund, A. (2008). Telemedicine: A policy analysis for quality, impact on patient outcomes, and policy feasibility. Nursing Perspectives, 56(4), 152-158.Schlachta-Fairchild, L. (2001). Telemedicine: a new venue for healthcare delivery. In Oncology nursing seminars (Vol. 17, No. 1, pp. 34-40). W. B. Saunders.Sorrells-Jones, J., Tschirch, P., & Liong, M. A. S. (2006). Nursing and telehealth: Opportunities for nurse leaders to shape the future. Nurse Leader, 4(5), 42-58. Walsh, M., & Coleman, J. R. (2005). Trials and tribulations: A small telehealth home care pilot program for Medicare patients. Geriatric nursing, 26(6), 343-346.