IntroductionThe venom of the king cobra is highly neurotoxic to humans and, if untreated, can cause death within hours from respiratory failure. (Norris, 2008) This article will review the neurotoxic effects of king cobra venom on the central nervous system at the neuromuscular junction, signs and symptoms of envenomation, antivenom and supportive measures, and prognosis. The movement of the neuromuscular junction of voluntary muscles is controlled by the central nervous system. The impulses originate in the brain and are carried to the muscles by neurons. Each individual neuron is made up of the dendrites, the cell body and the axon. Dendrites are branched projections that collect nerve impulses and transmit them to the cell body. The impulse is then sent from the cell body through the axon to another neuron, until it reaches the neuromuscular junction. (Shier, D. et all) The neuromuscular junction is where the neuron's axon meets the muscle fibers. There is a small space between the axon and the muscle fibers, called the synaptic cleft, through which the nerve impulse must travel to produce movement in the muscle. (Shier, D. et al, 2004, p.282-283) One of the ways in which impulse can be transmitted across the synaptic cleft is through the use of chemicals, called neurotransmitters. Acetylcholine is a neurotransmitter used in the neuromuscular junction of motor neurons and voluntary muscles. The end of the motor neuron axon contains small vesicles that store acetylcholine. When a nerve impulse reaches the neuron, calcium enters the cell and stimulates these vesicles to release acetylcholine into the synaptic cleft. The acetylcholine travels through the crack and attaches to the ac...... center of the card ......ability of late serum sickness. According to Warrell, D., "snake bite (in Southeast Asia) is an occupational hazard that is very difficult to avoid completely. People should be aware of what types of snakes live locally, their preferred habitat, and when they are most active.When walking in jungle or tall grass you should wear appropriate footwear and clothing approached with caution, dead or alive. (Warrell, D.) Conclusion King cobra envenomation will rapidly affect the central nervous system, inhibiting the release and reception of acetylcholine, causing death from respiratory failure be neutralized by administration of the appropriate antidote and the patient's life can be saved.